A variety night in Acomb will help raise funds for a charity supporting people with mitochondrial disease.
The event will take place at the Holgate Club on October 17 in aid of The Lily Foundation.
Tickets are available at the door.
Ian Wood, a 48-year-old man who is registered blind, uses a wheelchair, and lives with the condition, will be performing a comedy routine later in the month.
Mr Wood said: "On October 31, 4-5pm, and November 1, 12-1pm, I am taking part in the Yorkshire fringe, doing some stand-up comedy, talking about my autobiography and including some funny stories of incidents that have happened over the last few years."
His fringe performances will be held at Beeforth's Hive in Scarborough.